Men's natural hatred against God

"They are mortal enemies to God; i.e. they have that enmity in their hearts, that strikes at the life of God. A man maybe no friend to another, and may have an ill spirit towards him; and yet not be his mortal enemy. His enmity will be satisfied with something short of the death of the person. But it is not so with natural men, with respect to God. They are mortal enemies. Their imbecility is no argument that this is not the tendency of the principle.

Natural men are enemies to the dominion of God; and their nature shows their good-will to dethrone him if they could! Yea, they are enemies to the being of God, and would be glad if there was no God. And therefore it necessarily follows, that they would cause that there should be none, if they could. Psa. 14:1, “The fool hath said in his heart, There is no God.” This implies, not only an aptness to question the being of God; but, that he inclines it should be so. His heart says, i.e. his inclination says. The words in the original are, “The fool hath said in his heart, No God.” That is, I would have none, I do not desire any, I wish there was none; that would suit my inclination best. Let the world be emptied of a God, he stands in my way. And hence he is an atheist in his heart....

...The divine nature being immortal, and infinitely out of our reach, there is no other trial possible, whether the enmity that is naturally in the heart against God, be mortal or no, but only for God to take on him the human nature, and become man; so as to come within man’s reach. There can be no other experiment. And what has been the event? Why, when once God became man, and came down to dwell here, among such vipers as fallen men, they hated and persecuted him; and never desisted till they had imbrued their hands in his blood. There was a multitude of them that appeared combined in this design. Nothing would do, but he must be put to death. All cry out, Crucify him, crucify him. Away with him. They had rather Barabbas who greatly deserved death, should live, than he should not die. Nothing would restrain them from it; even all his preaching, and all his miracles. But they would kill him. And it was not the ordinary kind of execution that would satisfy them; but it must be the most cruel and most ignominious they possibly could invent. And they aggravated it as much as they could, by mocking him, and spitting on him, and scourging him. This shows what the nature and tendency of man’s enmity against God is; here it appeared in its true colors."

From a sermon entitled Men naturally are God's enemies, by Jonathan Edwards.